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Diabetes Metab Syndr ; 15(6): 102322, 2021.
Article in English | MEDLINE | ID: covidwho-1482539

ABSTRACT

BACKGROUND AND AIMS: Mucormycosis is an invasive fungal infection and carries a significant morbidity and mortality. A number of cases of mucormycosis have been reported in association with COVID-19. In this study, a consortium of clinicians from various parts of India studied clinical profile of COVID-19 associated mucormycosis (CAM) and this analysis is presented here. METHODS: Investigators from multiple sites in India were involved in this study. Clinical details included the treatment and severity of COVID-19, associated morbidities, as well as the diagnosis, treatment and prognosis of mucormycosis. These data were collected using google spreadsheet at one centre. Descriptive analysis was done. RESULTS: There were 115 patients with CAM. Importantly, all patients had received corticosteroids. Diabetes was present in 85.2% of patients and 13.9% of patients had newly detected diabetes. The most common site of involvement was rhino-orbital. Mortality occurred in 25 (21.7%) patients. On logistic regression analysis, CT scan-based score for severity of lung involvement was associated with mortality. CONCLUSION: Universal administration of corticosteroids in our patients is notable. A large majority of patients had diabetes, while mortality was seen in ∼1/5th of patients, lower as compared to recently published data.


Subject(s)
Adrenal Cortex Hormones/adverse effects , COVID-19/complications , Diabetes Complications/virology , Mucormycosis/virology , Adult , Aged , Comorbidity , Diabetes Complications/mortality , Female , Humans , India/epidemiology , Male , Middle Aged , Mucormycosis/chemically induced , Mucormycosis/mortality , Retrospective Studies , Risk Factors , COVID-19 Drug Treatment
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